Open Your Eyes to a More Refreshed, Lifted Look
UPNEEQ is the first and only FDA-approved prescription eye drop clinically proven to lift low-lying eyelids without surgery.
Schedule a Virtual ConsultationWhat Is UPNEEQ?
UPNEEQ (oxymetazoline hydrochloride ophthalmic solution, 0.1%) is the first and only FDA-approved prescription eye drop designed to treat acquired blepharoptosis, the clinical term for low-lying or drooping upper eyelids. Just one drop per day is clinically proven to lift the upper eyelid, giving your eyes a more open, awake, and refreshed appearance in minutes.
Unlike surgical eyelid correction, UPNEEQ requires no downtime, no incisions, and no recovery. It works by stimulating the Muller's muscle in the upper eyelid, a muscle responsible for eyelid elevation, causing it to contract and gently lift the lid. The result is a subtle but noticeable improvement that makes your eyes look more alert and youthful throughout the day.
We now offer UPNEEQ at VIOSA Aesthetics MD, prescribed and overseen by Jose Ruiz, M.D., Board Certified in Internal Medicine. Virtual consultations are available for new and existing patients interested in this treatment.
4 Reasons to Try UPNEEQ
FDA-Approved and Clinically Proven
UPNEEQ is the first and only prescription eye drop approved by the FDA specifically for the treatment of acquired low-lying eyelids in adults. Its safety and effectiveness were established across multiple clinical trials involving hundreds of patients, giving you confidence in what you are using.
No Surgery, No Downtime
If drooping eyelids have been affecting your appearance or confidence, UPNEEQ offers a non-surgical path forward. There are no incisions, no anesthesia, and no recovery period. One drop in the morning fits easily into your daily routine, and results are visible in as little as 5 minutes after the first dose.
Fast, Noticeable Results
In clinical studies, 84% of patients experienced some level of improvement, and 74% had more than 50% improvement in eyelid lift. The average lift was approximately 1 mm, which is enough to create a meaningful, visible difference in how open and alert your eyes appear throughout the day.
Physician-Prescribed and Supervised
At VIOSA Aesthetics MD, UPNEEQ is prescribed exclusively by Jose Ruiz, M.D., a Board Certified Internal Medicine physician. We review your health history and current medications before prescribing to ensure this treatment is safe and appropriate for you. You receive the attention and expertise of a medical provider, not just a product.
The Benefits of UPNEEQ
Lifted Upper Eyelids
Gently elevates the eyelid for a more open, refreshed appearance
Fast Acting
Some patients see results in as little as 5 minutes after the first drop
FDA Approved
The only prescription drop approved specifically for low-lying eyelids in adults
Once Daily Use
Simple one drop per eye daily routine with results lasting at least 6 hours
No Surgery Required
A non-invasive alternative to blepharoplasty with zero downtime or recovery
Youthful Appearance
Opens the eye area to create a more awake, energized, and youthful look
Physician Supervised
Prescribed and monitored by Jose Ruiz, M.D., Board Certified in Internal Medicine
Virtual Consultations
Receive your UPNEEQ prescription through a convenient virtual appointment from home
The Science and Safety of UPNEEQ
UPNEEQ is backed by extensive clinical research and has been rigorously reviewed by the FDA. Here is what the science says.
How It Works
UPNEEQ contains oxymetazoline hydrochloride, an alpha adrenergic agonist that acts on the Muller's muscle in the upper eyelid. When one drop is applied, the active ingredient stimulates this muscle to contract, which raises the upper eyelid and opens the eye. This is the same class of active ingredient found in decongestant nasal sprays, but here it is formulated specifically for ophthalmic use to target eyelid elevation rather than nasal vessels.
Each single-use vial contains enough solution to treat one or both eyes. Results have been shown to last at least 6 hours per dose in clinical studies, and some patients experience effects for up to 8 to 10 hours.
Clinical Evidence
FDA approval for UPNEEQ was supported by two 6-week clinical trials involving 304 adults with acquired blepharoptosis, plus a third study confirming safety. Results showed that 84% of patients experienced improvement in eyelid lift, and 74% had more than 50% improvement. The average upper eyelid lift across studies was approximately 1 mm, which is clinically meaningful for both appearance and field of vision.
The most commonly observed side effects, reported in 1 to 5% of study participants, included mild eye inflammation, redness, dry eye, blurred vision, eye irritation, and headache. UPNEEQ should not be used by patients with certain underlying conditions including cardiovascular issues, uncontrolled hypertension, or specific neurological conditions. A physician review before prescribing is essential, which is why we require a consultation before dispensing.
See the Difference One Drop Can Make
Tired-looking eyes and uneven lids no longer require surgery. UPNEEQ gives you a clinically proven, physician-supervised option that works in minutes and fits into your daily routine.
Call or Text to Schedule Your ConsultationFrequently Asked Questions
UPNEEQ is approved for adults with acquired blepharoptosis, which is the medical term for low-lying or drooping upper eyelids. Ideal candidates are adults who notice one or both eyelids sitting lower than they used to, whether from aging, prior BOTOX treatment, or other factors. Patients with certain cardiovascular, neurological, or eye conditions may not be candidates, which is why we always require a consultation and health review before prescribing.
We offer virtual consultations for UPNEEQ, which means you can meet with Jose Ruiz, M.D. from the comfort of your home. During the consultation, we review your health history, current medications, and symptoms to determine if UPNEEQ is right for you. If appropriate, a prescription will be issued and we will walk you through next steps for obtaining your drops. To get started, simply call or text our office at 562-400-7970.
Some patients in clinical studies saw visible eyelid lift in as little as 5 minutes after the first dose. Most patients experience noticeable improvement within 2 hours of application. The effects of a single drop have been shown to last at least 6 hours, and some patients experience benefits for up to 8 to 10 hours. Since it is a once-daily treatment, you apply one drop in the morning and enjoy the results throughout your day.
UPNEEQ is generally well tolerated. In clinical trials, side effects occurred in 1 to 5% of patients and included mild eye inflammation, eye redness, dry eye, blurred vision, eye pain or irritation at the time of use, and headache. These effects were generally minor and resolved without treatment. During your consultation, we will discuss your full health history to ensure UPNEEQ is safe for you and to address any concerns before starting treatment.
Yes. UPNEEQ is commonly used by patients who experience low-lying eyelids as a side effect of BOTOX or other wrinkle relaxer treatments. It can provide temporary correction while the neurotoxin wears off or serve as an ongoing maintenance treatment for patients with acquired ptosis. During your consultation, we will review all current treatments and medications to determine the best and safest approach for your specific situation.
Ready to Lift, Brighten, and Refresh Your Eyes?
UPNEEQ is available now at VIOSA Aesthetics MD. Call or text our office to schedule your virtual appointment with Jose Ruiz, M.D. and find out if UPNEEQ is right for you.
